Cargando…

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis

SIMPLE SUMMARY: In eukaryotes, MAPK15 controls the assembly of primary cilia, which are microtubule-based cell surface organelles necessary for sensing and processing developmental signals as well as for transducing tumorigenic Hedgehog signaling in medulloblastomas and basal cell carcinomas. The ai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pietrobono, Silvia, Franci, Lorenzo, Imperatore, Francesco, Zanini, Cristina, Stecca, Barbara, Chiariello, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508543/ https://www.ncbi.nlm.nih.gov/pubmed/34638386 http://dx.doi.org/10.3390/cancers13194903

Ejemplares similares

Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
por: Pietrobono, Silvia, et al.
Publicado: (2023)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
por: Pietrobono, Silvia, et al.
Publicado: (2019)

Regulation of melanoma initiating cells by Hedgehog signaling and SOX2
por: Santini, Roberta, et al.
Publicado: (2014)

Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe
por: Pietrobono, Silvia, et al.
Publicado: (2018)

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling
por: Liu, Pengfei, et al.
Publicado: (2020)

MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process
por: Franci, Lorenzo, et al.
Publicado: (2022)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
por: Pietrobono, Silvia, et al.
Publicado: (2018)

Aberrant Sialylation in Cancer: Biomarker and Potential Target for Therapeutic Intervention?
por: Pietrobono, Silvia, et al.
Publicado: (2021)

Decoding the Roles of Astrocytes and Hedgehog Signaling in Medulloblastoma
por: Duarte, Terence Teixeira, et al.
Publicado: (2021)

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling
por: Martin-Hurtado, Ana, et al.
Publicado: (2019)

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy
por: Pandolfi, Silvia, et al.
Publicado: (2015)

Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors
por: Azatyan, Ani, et al.
Publicado: (2021)

A non-canonical Hedgehog pathway initiates ciliogenesis and autophagy
por: Akhshi, Tara, et al.
Publicado: (2020)

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice
por: Snouffer, Ashley, et al.
Publicado: (2017)

Emerging Roles of Hedgehog Signaling in Cancer Immunity
por: Giammona, Alessandro, et al.
Publicado: (2023)

The Role of Glycosylation in Melanoma Progression
por: De Vellis, Chiara, et al.
Publicado: (2021)

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
por: Stecca, Barbara, et al.
Publicado: (2002)

Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse
por: Bangs, Fiona K., et al.
Publicado: (2020)

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
por: Yoshida, Saishu, et al.
Publicado: (2020)

KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling
por: Pejskova, Petra, et al.
Publicado: (2020)

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma
por: Huang, Sherri Y., et al.
Publicado: (2015)

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex
por: Mann, Beth, et al.
Publicado: (2023)

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells
por: Scheidt, Tamara, et al.
Publicado: (2020)

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
por: Qu, Meiyu, et al.
Publicado: (2022)

p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells
por: Pietrobono, Silvia, et al.
Publicado: (2022)

The Role of the Hedgehog Pathway in Cholangiocarcinoma
por: Anichini, Giulia, et al.
Publicado: (2021)

p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
por: Cain, Jason E., et al.
Publicado: (2020)

Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy
por: Montagnani, Valentina, et al.
Publicado: (2019)

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2
por: Spiombi, Eleonora, et al.
Publicado: (2019)

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
por: Jenkins, Noah C, et al.
Publicado: (2014)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
por: Bell, Jonathan B., et al.
Publicado: (2018)

Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling
por: Liu, Xiaotong, et al.
Publicado: (2016)

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development
por: Lee, Hankyu, et al.
Publicado: (2020)

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
por: Sivakumar, Sushama, et al.
Publicado: (2022)

Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma
por: Pietrobono, Silvia, et al.
Publicado: (2021)

Centrobin controls primary ciliogenesis in vertebrates
por: Ogungbenro, Yetunde Adesanya, et al.
Publicado: (2018)

Nonredundant roles of DIAPHs in primary ciliogenesis
por: Palander, Oliva, et al.
Publicado: (2021)

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
por: Raducu, Madalina, et al.
Publicado: (2016)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
por: Chahal, Kirti Kandhwal, et al.
Publicado: (2019)

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
por: Kim, Hyejeong Rosemary, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ddt473026hd4l3ab9k4t0be4jo