Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells

Micro-RNA-21 (miR-21) is a vital regulator of colorectal cancer (CRC) progression and has emerged as a potential therapeutic target in CRC treatment. Our study using real-time PCR assay found that a secondary bile acid, lithocholic acid (LCA), stimulated the expression of miR21 in the CRC cell lines...

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Detalles Bibliográficos
Autores principales: Nguyen, Thinh-Thi, Ung, Thuan-Trong, Li, Shinan, Sah, Dhiraj Kumar, Park, Sun-Young, Lian, Sen, Jung, Young-Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508661/
https://www.ncbi.nlm.nih.gov/pubmed/34638550
http://dx.doi.org/10.3390/ijms221910209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508661/
https://www.ncbi.nlm.nih.gov/pubmed/34638550
http://dx.doi.org/10.3390/ijms221910209

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