Cargando…

Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model

Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused by activated microglia and infiltrated immune cells. How to successfully balance neuroprotective versus neurotoxic actions through the use of anti-inflammatory agents is still under debate. There has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Apolloni, Savina, Fabbrizio, Paola, Amadio, Susanna, Napoli, Giulia, Freschi, Mattia, Sironi, Francesca, Pevarello, Paolo, Tarroni, Paola, Liberati, Chiara, Bendotti, Caterina, Volonté, Cinzia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508678/ https://www.ncbi.nlm.nih.gov/pubmed/34638992 http://dx.doi.org/10.3390/ijms221910649

Ejemplares similares

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression
por: Apolloni, Savina, et al.
Publicado: (2016)

P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
por: Fabbrizio, Paola, et al.
Publicado: (2017)

Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS
por: Apolloni, Savina, et al.
Publicado: (2019)

Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis
por: Apolloni, Savina, et al.
Publicado: (2017)

P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
por: Fabbrizio, Paola, et al.
Publicado: (2019)

Stimulation of P2X7 Enhances Whole Body Energy Metabolism in Mice
por: Giacovazzo, Giacomo, et al.
Publicado: (2019)

Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
por: Apolloni, Savina, et al.
Publicado: (2014)

Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis
por: Volonté, Cinzia, et al.
Publicado: (2020)

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis
por: Amadio, Susanna, et al.
Publicado: (2017)

P2Y(12) Receptor on the Verge of a Neuroinflammatory Breakdown
por: Amadio, Susanna, et al.
Publicado: (2014)

Histaminergic transmission slows progression of amyotrophic lateral sclerosis
por: Apolloni, Savina, et al.
Publicado: (2019)

Counteracting roles of MHCI and CD8(+) T cells in the peripheral and central nervous system of ALS SOD1(G93A) mice
por: Nardo, Giovanni, et al.
Publicado: (2018)

Altered Metabolic Profiles Associate with Toxicity in SOD1(G93A) Astrocyte-Neuron Co-Cultures
por: Valbuena, Gabriel N., et al.
Publicado: (2017)

Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1(G93A) Amyotrophic Lateral Sclerosis
por: Valbuena, Gabriel N., et al.
Publicado: (2019)

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1(G93A) mice
por: Scaricamazza, Silvia, et al.
Publicado: (2022)

Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice
por: Trolese, Maria Chiara, et al.
Publicado: (2022)

MicroRNA-125b regulates microglia activation and motor neuron death in ALS
por: Parisi, C, et al.
Publicado: (2016)

Immune response in peripheral axons delays disease progression in SOD1(G93A) mice
por: Nardo, Giovanni, et al.
Publicado: (2016)

Amyotrophic lateral sclerosis disease burden: doing better at getting better
por: Volonté, Cinzia, et al.
Publicado: (2022)

Repurposing Histaminergic Drugs in Multiple Sclerosis
por: Amadio, Susanna, et al.
Publicado: (2022)

Where and Why Modeling Amyotrophic Lateral Sclerosis
por: Liguori, Francesco, et al.
Publicado: (2021)

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue
por: Vallarola, Antonio, et al.
Publicado: (2018)

Gamisoyo-San Ameliorates Neuroinflammation in the Spinal Cord of hSOD1(G93A) Transgenic Mice
por: Cai, MuDan, et al.
Publicado: (2018)

Intramuscular IL-10 Administration Enhances the Activity of Myogenic Precursor Cells and Improves Motor Function in ALS Mouse Model
por: Fabbrizio, Paola, et al.
Publicado: (2023)

Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study
por: Amadio, Susanna, et al.
Publicado: (2007)

CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis
por: Trolese, Maria Chiara, et al.
Publicado: (2020)

The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model
por: Di Sante, Gabriele, et al.
Publicado: (2020)

Neuromuscular effects of G93A-SOD1 expression in zebrafish
por: Sakowski, Stacey A, et al.
Publicado: (2012)

P2Y(1 )receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex
por: Amadio, Susanna, et al.
Publicado: (2007)

The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis
por: Galbiati, Mariarita, et al.
Publicado: (2012)

Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1(G93A) model of amyotrophic lateral sclerosis
por: Huang, G, et al.
Publicado: (2013)

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Song, Lin, et al.
Publicado: (2014)

Plasticity of primary microglia on micropatterned geometries and spontaneous long-distance migration in microfluidic channels
por: Amadio, Susanna, et al.
Publicado: (2013)

Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically
por: Paizs, Melinda, et al.
Publicado: (2011)

Metabolic Changes Associated With Muscle Expression of SOD1(G93A)
por: Dobrowolny, Gabriella, et al.
Publicado: (2018)

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model
por: Ionescu, Ariel, et al.
Publicado: (2019)

ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS
por: Bonafede, Roberta, et al.
Publicado: (2020)

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1(G93A) Mouse Model of ALS by Enhancing Autophagic Flux
por: Zhang, Xiaojie, et al.
Publicado: (2019)

Retracted: Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: BioMed Research International,
Publicado: (2019)

Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates
por: Borel, Florie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3kv108i48pms288uiubmf4qcjv