Poly ADP Ribose Polymerase Inhibitor Olaparib Targeting Microhomology End Joining in Retinoblastoma Protein Defective Cancer: Analysis of the Retinoblastoma Cell-Killing Effects by Olaparib after Inducing Double-Strand Breaks

Retinoblastoma is the most common intraocular cancer in childhood. Loss of function in both copies of the RB1 gene is the causal mutation of retinoblastoma. Current treatment for retinoblastoma includes the use of chemotherapeutic agents, such as the DNA damaging agent etoposide, which is a topoisom...

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Detalles Bibliográficos
Autores principales: Jiang, Yuning, Yam, Jason C., Chu, Wai Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508856/
https://www.ncbi.nlm.nih.gov/pubmed/34639028
http://dx.doi.org/10.3390/ijms221910687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508856/
https://www.ncbi.nlm.nih.gov/pubmed/34639028
http://dx.doi.org/10.3390/ijms221910687

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