Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers in humans. At early stages CRC is treated by surgery and at advanced stages combined with chemotherapy. We examined here the potential effect of glucosylceramide synthase (GCS)-inhibition on CRC biology. GCS is the rate-limiting...

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Detalles Bibliográficos
Autores principales: Jennemann, Richard, Volz, Martina, Bestvater, Felix, Schmidt, Claudia, Richter, Karsten, Kaden, Sylvia, Müthing, Johannes, Gröne, Hermann-Josef, Sandhoff, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508865/
https://www.ncbi.nlm.nih.gov/pubmed/34638879
http://dx.doi.org/10.3390/ijms221910539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508865/
https://www.ncbi.nlm.nih.gov/pubmed/34638879
http://dx.doi.org/10.3390/ijms221910539

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