Cyclic GMP in Liver Cirrhosis—Role in Pathophysiology of Portal Hypertension and Therapeutic Implications

The NO-cGMP signal transduction pathway plays a crucial role in tone regulation in hepatic sinusoids and peripheral blood vessels. In a cirrhotic liver, the key enzymes endothelial NO synthase (eNOS), soluble guanylate cyclase (sGC), and phosphodiesterase-5 (PDE-5) are overexpressed, leading to decr...

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Detalles Bibliográficos
Autores principales: Kreisel, Wolfgang, Lazaro, Adhara, Trebicka, Jonel, Grosse Perdekamp, Markus, Schmitt-Graeff, Annette, Deibert, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508925/
https://www.ncbi.nlm.nih.gov/pubmed/34638713
http://dx.doi.org/10.3390/ijms221910372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508925/
https://www.ncbi.nlm.nih.gov/pubmed/34638713
http://dx.doi.org/10.3390/ijms221910372

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