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Cyclic GMP in Liver Cirrhosis—Role in Pathophysiology of Portal Hypertension and Therapeutic Implications

The NO-cGMP signal transduction pathway plays a crucial role in tone regulation in hepatic sinusoids and peripheral blood vessels. In a cirrhotic liver, the key enzymes endothelial NO synthase (eNOS), soluble guanylate cyclase (sGC), and phosphodiesterase-5 (PDE-5) are overexpressed, leading to decr...

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Detalles Bibliográficos
Autores principales:	Kreisel, Wolfgang, Lazaro, Adhara, Trebicka, Jonel, Grosse Perdekamp, Markus, Schmitt-Graeff, Annette, Deibert, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508925/ https://www.ncbi.nlm.nih.gov/pubmed/34638713 http://dx.doi.org/10.3390/ijms221910372

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