Adenovirus Vectors Expressing Eight Multiplex Guide RNAs of CRISPR/Cas9 Efficiently Disrupted Diverse Hepatitis B Virus Gene Derived from Heterogeneous Patient

Hepatitis B virus (HBV) chronically infects more than 240 million people worldwide, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Genome editing using CRISPR/Cas9 could provide new therapies because it can directly disrupt HBV genomes. However, because HBV genome sequence...

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Detalles Bibliográficos
Autores principales: Kato, Yuya, Tabata, Hirotaka, Sato, Kumiko, Nakamura, Mariko, Saito, Izumu, Nakanishi, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508944/
https://www.ncbi.nlm.nih.gov/pubmed/34638909
http://dx.doi.org/10.3390/ijms221910570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508944/
https://www.ncbi.nlm.nih.gov/pubmed/34638909
http://dx.doi.org/10.3390/ijms221910570

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