Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect

A new series of 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine linked sulfonamide derivatives 12a–n was designed and synthesized according to the structure of well-established V600EBRAF inhibitors. The terminal sulfonamide moiety was linked to the pyrimidine ring via either ethylamine or propylamine...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdel-Maksoud, Mohammed S., Mohamed, Ahmed A. B., Hassan, Rasha M., Abdelgawad, Mohamed A., Chilingaryan, Garri, Selim, Samy, Abdel-Bakky, Mohamed S., Al-Sanea, Mohammad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508980/
https://www.ncbi.nlm.nih.gov/pubmed/34638829
http://dx.doi.org/10.3390/ijms221910491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508980/
https://www.ncbi.nlm.nih.gov/pubmed/34638829
http://dx.doi.org/10.3390/ijms221910491

Ejemplares similares