Cargando…

A Method to Monitor the NAD(+) Metabolome—From Mechanistic to Clinical Applications

Nicotinamide adenine dinucleotide (NAD(+)) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD(+) also serves as a substrate for enzymes such as sirtuins, poly(ADP-ribose) polymerases (PARPs) and ADP-ribosyl cyclases. Given the pivotal role of NAD(H) in health...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giner, Maria Pilar, Christen, Stefan, Bartova, Simona, Makarov, Mikhail V., Migaud, Marie E., Canto, Carles, Moco, Sofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508997/ https://www.ncbi.nlm.nih.gov/pubmed/34638936 http://dx.doi.org/10.3390/ijms221910598

Ejemplares similares

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor
por: Giroud-Gerbetant, Judith, et al.
Publicado: (2019)

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD(+) by Generating Dihydronicotinamide Riboside
por: Ciarlo, Eleonora, et al.
Publicado: (2022)

NAD(+) Precursors: A Questionable Redundancy
por: Canto, Carles
Publicado: (2022)

NAD Metabolome Analysis in Human Cells Using (1)H NMR Spectroscopy
por: Shabalin, Konstantin, et al.
Publicado: (2018)

Defining NAD(P)(H) Catabolism
por: Dhuguru, Jyothi, et al.
Publicado: (2023)

Studying Metabolism by NMR-Based Metabolomics
por: Moco, Sofia
Publicado: (2022)

Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations
por: Cercillieux, Angelique, et al.
Publicado: (2022)

Editorial: NAD+ metabolism as a novel target against infection–Volume II
por: Balducci, Enrico, et al.
Publicado: (2022)

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives
por: Makarov, Mikhail V, et al.
Publicado: (2019)

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD
por: Sverkeli, Lars Jansen, et al.
Publicado: (2021)

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration
por: Sonntag, Tanja, et al.
Publicado: (2022)

Degradation of Extracellular NAD(+) Intermediates in Cultures of Human HEK293 Cells
por: Kulikova, Veronika, et al.
Publicado: (2019)

The human NAD metabolome: Functions, metabolism and compartmentalization
por: Nikiforov, Andrey, et al.
Publicado: (2015)

The Plasma NAD(+) Metabolome Is Dysregulated in “Normal” Aging
por: Clement, James, et al.
Publicado: (2019)

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD(+)/SIRT6 axis
por: Koczor, Christopher A., et al.
Publicado: (2021)

Structural and mechanistic basis of the mammalian Nudt12 RNA deNADding
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2019)

Synthesis of Mixed Dinucleotides by Mechanochemistry
por: Hayat, Faisal, et al.
Publicado: (2022)

NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

Quantification of Protein Copy Number in Yeast: The NAD(+) Metabolome
por: Mei, Szu-Chieh, et al.
Publicado: (2014)

Enhancing NAD(+) Metabolome in Cardiovascular Diseases: Promises and Considerations
por: Jahan, Fahmida, et al.
Publicado: (2021)

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
por: Sambeat, Audrey, et al.
Publicado: (2019)

Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites
por: Trammell, Samuel AJ, et al.
Publicado: (2013)

Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress
por: Sonavane, Manoj, et al.
Publicado: (2020)

Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD(+) Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase
por: Li, Jianfeng, et al.
Publicado: (2022)

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+
por: Grant, Ross, et al.
Publicado: (2019)

NAD+-Increasing Strategies to Improve Cardiometabolic Health?
por: Blanco-Vaca, Francisco, et al.
Publicado: (2022)

Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities
por: Migliavacca, Eugenia, et al.
Publicado: (2019)

SLC25A51 is a mammalian mitochondrial NAD(+) transporter
por: Luongo, Timothy S., et al.
Publicado: (2020)

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity
por: Heer, Collin D., et al.
Publicado: (2020)

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
por: Heer, Collin D., et al.
Publicado: (2021)

Extracellular NAD(+) enhances PARP-dependent DNA repair capacity independently of CD73 activity
por: Wilk, Anna, et al.
Publicado: (2020)

Dihydronicotinamide Riboside Is a Potent NAD(+) Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
por: Chini, Claudia C. S., et al.
Publicado: (2022)

“NAD-capQ” detection and quantitation of NAD caps
por: Grudzien-Nogalska, Ewa, et al.
Publicado: (2018)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Qualitative and Quantitative NAD(+) Metabolomics Lead to Discovery of Multiple Functional Nicotinate N-Glycosyltransferase in Arabidopsis
por: Liu, Lingyun, et al.
Publicado: (2019)

Metabolomics to Predict Antiviral Drug Efficacy in COVID-19
por: Migaud, Marie, et al.
Publicado: (2020)

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
por: Chareyron, Isabelle, et al.
Publicado: (2020)

Cloning and Organelle Expression of Bamboo Mitochondrial Complex I Subunits Nad1, Nad2, Nad4, and Nad5 in the Yeast Saccharomyces cerevisiae
por: Tsai, Hsieh-Chin, et al.
Publicado: (2022)

NAD to the rescue
por: Tuma, Rabiya S.
Publicado: (2005)

NAD-seq for profiling the NAD(+) capped transcriptome of Arabidopsis thaliana
por: Yu, Xiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_krrg304mc54rf2h7vt3d3q7ijs