Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks?
Background: Stroke remains a leading cause of death and disability throughout the world. It is well established that Diabetes Mellitus (DM) is a risk factor for stroke, while other risk factors include dyslipidaemia and hypertension. Given that the global prevalence of diabetes steadily increases, t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509285/ https://www.ncbi.nlm.nih.gov/pubmed/34640636 http://dx.doi.org/10.3390/jcm10194620 |
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author | Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos |
author_facet | Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos |
author_sort | Penlioglou, Theano |
collection | PubMed |
description | Background: Stroke remains a leading cause of death and disability throughout the world. It is well established that Diabetes Mellitus (DM) is a risk factor for stroke, while other risk factors include dyslipidaemia and hypertension. Given that the global prevalence of diabetes steadily increases, the need for adequate glycaemic control and prevention of DM-related cardiovascular events remains a challenge for the medical community. Therefore, a re-examination of the latest data related to this issue is of particular importance. Objective: This review aims to summarise the latest data on the relationship between DM and stroke, including epidemiology, risk factors, pathogenesis, prevention and biomarkers. Methods: For this purpose, comprehensive research was performed on the platforms PubMed, Google Scholar and EMBASE with a combination of the following keywords: diabetes mellitus, stroke, macrovascular complications, diabetic stroke, cardiovascular disease. Conclusions: Much progress has been made in stroke in people with DM in terms of prevention and early diagnosis. In the field of prevention, the adaptation of the daily habits and the regulation of co-morbidity of individuals play a particularly important role. Simultaneously, the most significant revolution has been brought by the relatively new treatment options that offer protection to the cardiovascular system. Moreover, many prognostic and diagnostic biomarkers have been identified, paving the way for early and accurate diagnoses. However, to date, there are crucial points that remain controversial and need further clarification. |
format | Online Article Text |
id | pubmed-8509285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85092852021-10-13 Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos J Clin Med Review Background: Stroke remains a leading cause of death and disability throughout the world. It is well established that Diabetes Mellitus (DM) is a risk factor for stroke, while other risk factors include dyslipidaemia and hypertension. Given that the global prevalence of diabetes steadily increases, the need for adequate glycaemic control and prevention of DM-related cardiovascular events remains a challenge for the medical community. Therefore, a re-examination of the latest data related to this issue is of particular importance. Objective: This review aims to summarise the latest data on the relationship between DM and stroke, including epidemiology, risk factors, pathogenesis, prevention and biomarkers. Methods: For this purpose, comprehensive research was performed on the platforms PubMed, Google Scholar and EMBASE with a combination of the following keywords: diabetes mellitus, stroke, macrovascular complications, diabetic stroke, cardiovascular disease. Conclusions: Much progress has been made in stroke in people with DM in terms of prevention and early diagnosis. In the field of prevention, the adaptation of the daily habits and the regulation of co-morbidity of individuals play a particularly important role. Simultaneously, the most significant revolution has been brought by the relatively new treatment options that offer protection to the cardiovascular system. Moreover, many prognostic and diagnostic biomarkers have been identified, paving the way for early and accurate diagnoses. However, to date, there are crucial points that remain controversial and need further clarification. MDPI 2021-10-08 /pmc/articles/PMC8509285/ /pubmed/34640636 http://dx.doi.org/10.3390/jcm10194620 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Penlioglou, Theano Stoian, Anca Pantea Papanas, Nikolaos Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title | Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title_full | Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title_fullStr | Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title_full_unstemmed | Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title_short | Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks? |
title_sort | diabetes, vascular aging and stroke: old dogs, new tricks? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509285/ https://www.ncbi.nlm.nih.gov/pubmed/34640636 http://dx.doi.org/10.3390/jcm10194620 |
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