A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase

Guanylate cyclase-activating protein 1 (GCAP1), encoded by the GUCA1A gene, is a neuronal calcium sensor protein involved in shaping the photoresponse kinetics in cones and rods. GCAP1 accelerates or slows the cGMP synthesis operated by retinal guanylate cyclase (GC) based on the light-dependent lev...

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Detalles Bibliográficos
Autores principales: Biasi, Amedeo, Marino, Valerio, Dal Cortivo, Giuditta, Maltese, Paolo Enrico, Modarelli, Antonio Mattia, Bertelli, Matteo, Colombo, Leonardo, Dell’Orco, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509414/
https://www.ncbi.nlm.nih.gov/pubmed/34639157
http://dx.doi.org/10.3390/ijms221910809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509414/
https://www.ncbi.nlm.nih.gov/pubmed/34639157
http://dx.doi.org/10.3390/ijms221910809

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