Cargando…

The Phenoxyalkyltriazine Antagonists for 5-HT(6) Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases

Among the serotonin receptors, one of the most recently discovered 5-HT(6) subtype is an important protein target and its ligands may play a key role in the innovative treatment of cognitive disorders. However, none of its selective ligands have reached the pharmaceutical market yet. Recently, a new...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sudoł, Sylwia, Cios, Agnieszka, Jastrzębska-Więsek, Magdalena, Honkisz-Orzechowska, Ewelina, Mordyl, Barbara, Wilczyńska-Zawal, Natalia, Satała, Grzegorz, Kucwaj-Brysz, Katarzyna, Partyka, Anna, Latacz, Gniewomir, Olejarz-Maciej, Agnieszka, Wesołowska, Anna, Handzlik, Jadwiga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509428/ https://www.ncbi.nlm.nih.gov/pubmed/34639113 http://dx.doi.org/10.3390/ijms221910773

Ejemplares similares

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT(6) Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
por: Latacz, Gniewomir, et al.
Publicado: (2019)

Selective 5-HT(6) Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats
por: Partyka, Anna, et al.
Publicado: (2023)

Effect of 5-HT(6) Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats
por: Wesołowska, Anna, et al.
Publicado: (2021)

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
por: Kurczab, Rafał, et al.
Publicado: (2018)

N-Skatyltryptamines—Dual 5-HT(6)R/D(2)R Ligands with Antipsychotic and Procognitive Potential
por: Hogendorf, Agata, et al.
Publicado: (2021)

Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
por: Latacz, Gniewomir, et al.
Publicado: (2022)

New Triazine Derivatives as Serotonin 5-HT(6) Receptor Ligands
por: Łażewska, Dorota, et al.
Publicado: (2023)

Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2017)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A(2A) and Dual A(1)/A(2A) Receptor Affinity
por: Załuski, Michał, et al.
Publicado: (2023)

The Structural Determinants for α(1)-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives
por: Kucwaj-Brysz, Katarzyna, et al.
Publicado: (2021)

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT(1A) receptor partial agonists
por: Partyka, Anna, et al.
Publicado: (2020)

2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule
por: Buzun, Kamila, et al.
Publicado: (2022)

Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT(1A) Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile
por: Sniecikowska, Joanna, et al.
Publicado: (2020)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT(1A)/5-HT(7) Affinity and Its Antidepressant-like Activity
por: Zaręba, Przemysław, et al.
Publicado: (2022)

Multitargeting the Action of 5-HT(6) Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer’s Disease: Can It Work from a Molecular Point of View?
por: Czarnota-Łydka, Kinga, et al.
Publicado: (2022)

ADN-1184, a monoaminergic ligand with 5-HT(6/7) receptor antagonist action, exhibits activity in animal models of anxiety
por: Partyka, Anna, et al.
Publicado: (2016)

Selenazolinium Salts as “Small Molecule Catalysts” with High Potency against ESKAPE Bacterial Pathogens
por: Witek, Karolina, et al.
Publicado: (2017)

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile
por: Stefanowicz, Jacek, et al.
Publicado: (2018)

HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats
por: Lustyk, Klaudia, et al.
Publicado: (2022)

Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT(6) partial agonist in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2016)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT(1A) and 5-HT(7) Antagonists in Animal Models
por: Pytka, Karolina, et al.
Publicado: (2015)

Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia
por: Marcinkowska, Monika, et al.
Publicado: (2021)

Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity
por: Marć, Małgorzata Anna, et al.
Publicado: (2022)

Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance
por: Kaczor, Aneta, et al.
Publicado: (2020)

Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease
por: Godyń, Justyna, et al.
Publicado: (2022)

Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity
por: Tejchman, Waldemar, et al.
Publicado: (2019)

The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2022)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
por: Sadek, Bassem, et al.
Publicado: (2016)

1-Aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats
por: Popik, Piotr, et al.
Publicado: (2014)

The Significance of Halogen Bonding in Ligand–Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D(4) Receptor
por: Kurczab, Rafał, et al.
Publicado: (2019)

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
por: Mika, Kamil, et al.
Publicado: (2021)

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases
por: Załuski, Michał, et al.
Publicado: (2023)

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis
por: Witek, Karolina, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT(7) Receptor
por: Kułaga, Damian, et al.
Publicado: (2022)

The procognitive effects of leptin in the brain and their clinical implications
por: Paz-Filho, G, et al.
Publicado: (2010)

Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
por: Carrasco-Gallardo, Carlos, et al.
Publicado: (2012)

Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice
por: Kurach, Łukasz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f9sdfulvfq1rlfj0pium25pj15