Cargando…

ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape †

Leukemias derived from the MLL-AF9 rearrangement rely on dysfunctional transcriptional networks. ZNF521, a transcription co-factor implicated in the control of hematopoiesis, has been proposed to sustain leukemic transformation in collaboration with other oncogenes. Here, we demonstrate that ZNF521...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiarella, Emanuela, Aloisio, Annamaria, Scicchitano, Stefania, Todoerti, Katia, Cosentino, Emanuela G., Lico, Daniela, Neri, Antonino, Amodio, Nicola, Bond, Heather Mandy, Mesuraca, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509509/ https://www.ncbi.nlm.nih.gov/pubmed/34639154 http://dx.doi.org/10.3390/ijms221910814

Ejemplares similares

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers
por: Chiarella, Emanuela, et al.
Publicado: (2021)

ZNF521 Represses Osteoblastic Differentiation in Human Adipose-Derived Stem Cells
por: Chiarella, Emanuela, et al.
Publicado: (2018)

ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies
por: Mesuraca, Maria, et al.
Publicado: (2015)

Expression Profiling and Functional Implications of a Set of Zinc Finger Proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in Primary Osteoarthritic Articular Chondrocytes
por: Mesuraca, Maria, et al.
Publicado: (2014)

ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer
por: Bond, Heather M., et al.
Publicado: (2018)

Enhanced ZNF521 expression induces an aggressive phenotype in human ovarian carcinoma cell lines
por: Scicchitano, Stefania, et al.
Publicado: (2022)

The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway
por: Scicchitano, Stefania, et al.
Publicado: (2019)

ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia
por: Germano, Giuseppe, et al.
Publicado: (2017)

Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches
por: Mesuraca, Maria, et al.
Publicado: (2018)

Nasal Polyposis: Insights in Epithelial-Mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Zinc Finger 521 Modulates the Nrf2-Notch Signaling Pathway in Human Ovarian Carcinoma
por: Scicchitano, Stefania, et al.
Publicado: (2023)

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells
por: Spina, Raffaella, et al.
Publicado: (2013)

Recombinant TAT-BMI-1 fusion protein induces ex vivo expansion of human umbilical cord blood-derived hematopoietic stem cells
por: Codispoti, Bruna, et al.
Publicado: (2017)

Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish
por: Tan, Jiaqi, et al.
Publicado: (2018)

Corrigendum to “Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish”
por: Tan, Jiaqi, et al.
Publicado: (2022)

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair
por: Castaño, Julio, et al.
Publicado: (2016)

UMG Lenti: Novel Lentiviral Vectors for Efficient Transgene- and Reporter Gene Expression in Human Early Hematopoietic Progenitors
por: Chiarella, Emanuela, et al.
Publicado: (2014)

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
por: Johannessen, Julie A., et al.
Publicado: (2023)

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
por: Barone, Cristiana, et al.
Publicado: (2023)

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis
por: Sarrou, Evgenia, et al.
Publicado: (2020)

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression
por: Huang, Wei, et al.
Publicado: (2019)

The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia
por: Zhang, Kai, et al.
Publicado: (2023)

Deficit in Adipose Differentiation in Mesenchymal Stem Cells Derived from Chronic Rhinosinusitis Nasal Polyps Compared to Nasal Mucosal Tissue
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene
por: Menendez, Pablo, et al.
Publicado: (2009)

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
por: Bueno, Clara, et al.
Publicado: (2019)

The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein
por: Cao, Lu, et al.
Publicado: (2019)

Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations
por: Secker, Kathy-Ann, et al.
Publicado: (2020)

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
por: Taiana, Elisa, et al.
Publicado: (2020)

Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL
por: Ahmad, K, et al.
Publicado: (2014)

Editorial to the Special Issue “Recent Advances in Biochemical Mechanisms of Acute Myeloid Leukemia”
por: Mesuraca, Maria, et al.
Publicado: (2023)

Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation
por: Heuts, Branco M. H., et al.
Publicado: (2023)

ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer
por: Li, Li, et al.
Publicado: (2022)

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
por: Liu, Y, et al.
Publicado: (2014)

Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited
por: Gué, Michaël, et al.
Publicado: (2006)

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis
por: Trentin, Luca, et al.
Publicado: (2016)

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34(+) cells
por: Prieto, Cristina, et al.
Publicado: (2017)

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
por: Prange, K H M, et al.
Publicado: (2017)

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2019)

Protocol to establish a stable MLL-AF9_AML mouse model
por: Lu, Jun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8fnqvjtvh6i3p1pj6ouiivm55p