Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia

Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochondrial dysfunction are all proposed as contributors to age-associated muscle loss, but connections between these factors have not been established. We examined contractility, mitochondrial function, an...

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Detalles Bibliográficos
Autores principales: Su, Yu, Claflin, Dennis R., Huang, Meixiang, Davis, Carol S., Macpherson, Peter C. D., Richardson, Arlan, Van Remmen, Holly, Brooks, Susan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509582/
https://www.ncbi.nlm.nih.gov/pubmed/34639076
http://dx.doi.org/10.3390/ijms221910735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509582/
https://www.ncbi.nlm.nih.gov/pubmed/34639076
http://dx.doi.org/10.3390/ijms221910735

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