Cargando…

Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway

Psoriasis is a chronic inflammatory skin disease. Recently, lysophosphatidic acid (LPA)/LPAR5 signaling has been reported to be involved in both NLRP3 inflammasome activation in macrophages and keratinocyte activation to produce inflammatory cytokines, contributing to psoriasis pathogenesis. However...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Donghee, Kim, Hyo-Jin, Baek, Jin-Ok, Roh, Joo-Young, Jun, Hee-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509620/ https://www.ncbi.nlm.nih.gov/pubmed/34639115 http://dx.doi.org/10.3390/ijms221910777

Ejemplares similares

Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5
por: Lei, Li, et al.
Publicado: (2021)

Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy
por: Lee, Geon-Ho, et al.
Publicado: (2022)

Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma
por: He, Jian, et al.
Publicado: (2021)

Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages
por: Gaire, Bhakta Prasad, et al.
Publicado: (2020)

Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells
por: Zuckerman, Valentina, et al.
Publicado: (2015)

Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis
por: Takagi, Satoshi, et al.
Publicado: (2021)

Lysophosphatidic Acid Signaling in Diabetic Nephropathy
por: Lee, Jong Han, et al.
Publicado: (2019)

Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer
por: Liu, Xuemei, et al.
Publicado: (2022)

Anoctamin1 Induces Hyperproliferation of HaCaT Keratinocytes and Triggers Imiquimod-Induced Psoriasis-Like Skin Injury in Mice
por: Choi, Mi Ran, et al.
Publicado: (2021)

The Effect of Imiquimod on Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Malignant Melanoma Cell Invasion
por: Jung, Jin Young, et al.
Publicado: (2014)

IOX1 impedes host inflammation in imiquimod-triggered psoriasis
por: Shin, Joo Eun, et al.
Publicado: (2021)

Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
por: Kim, Donghee, et al.
Publicado: (2022)

Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice
por: Park, Eunhye, et al.
Publicado: (2017)

HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells
por: Kim, Nam-Ho, et al.
Publicado: (2019)

Lysophosphatidic Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (mTOR) Pathway
por: Wu, Cheng-Yong, et al.
Publicado: (2020)

LPAR1 regulates the development of intratumoral heterogeneity in ovarian serous cystadenocarcinoma by activating the PI3K/AKT signaling pathway
por: Cui, Ran, et al.
Publicado: (2019)

Augmentation of NAD(+) by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice
por: Lee, Seung Hoon, et al.
Publicado: (2022)

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells
por: Plastira, Ioanna, et al.
Publicado: (2019)

Roles of TLR7 in Activation of NF-κB Signaling of Keratinocytes by Imiquimod
por: Li, Zheng Jun, et al.
Publicado: (2013)

Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice
por: Gao, Jintao, et al.
Publicado: (2020)

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory
por: Lin, Yu-Nung, et al.
Publicado: (2020)

Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis
por: Choi, Minjee, et al.
Publicado: (2019)

Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2
por: Kim, Donghee, et al.
Publicado: (2023)

Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis
por: Chen, Yan, et al.
Publicado: (2015)

Long-Acting β(2) Adrenergic Receptor Agonist Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesion by Regulating Keratinocyte Proliferation and Apoptosis
por: Xu, Rui, et al.
Publicado: (2022)

Targeting TGF-β1/miR-21 Pathway in Keratinocytes Reveals Protective Effects of Silymarin on Imiquimod-Induced Psoriasis Mouse Model
por: Henriet, Elodie, et al.
Publicado: (2022)

Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways
por: Hsueh, Yi-Jen, et al.
Publicado: (2015)

Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study
por: Younis, Saima, et al.
Publicado: (2017)

Advanced Characterization of Imiquimod-Induced Psoriasis-Like Mouse Model
por: Jabeen, Mehwish, et al.
Publicado: (2020)

Alleviation of imiquimod-induced psoriasis-like symptoms in Rorα-deficient mouse skin
por: Park, Koog Chan, et al.
Publicado: (2023)

Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model
por: Lee, Young Bok, et al.
Publicado: (2014)

Alantolactone Suppresses Proliferation and the Inflammatory Response in Human HaCaT Keratinocytes and Ameliorates Imiquimod-Induced Skin Lesions in a Psoriasis-Like Mouse Model
por: Chuo, Wen-Ho, et al.
Publicado: (2021)

Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
por: Lee, Song Yi, et al.
Publicado: (2018)

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling
por: Kim, Donghee, et al.
Publicado: (2019)

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation
por: Lock, Frances E., et al.
Publicado: (2009)

Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice
por: Nguyen, Ly Thi Huong, et al.
Publicado: (2022)

Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice
por: Kjær, Thomas Nordstrøm, et al.
Publicado: (2015)

Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
por: Piro, Maria Cristina, et al.
Publicado: (2020)

Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis
por: Salman, Hayder R., et al.
Publicado: (2023)

Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes
por: Jang, Soyeon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c32j9vgcool22npq6dq97gb2gp