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Global Proteotoxicity Caused by Human β(2) Microglobulin Variants Impairs the Unfolded Protein Response in C. elegans
Aggregation of β(2) microglobulin (β(2)m) into amyloid fibrils is associated with systemic amyloidosis, caused by the deposition of amyloid fibrils containing the wild-type protein and its truncated variant, ΔN6 β(2)m, in haemo-dialysed patients. A second form of familial systemic amyloidosis caused...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509642/ https://www.ncbi.nlm.nih.gov/pubmed/34639093 http://dx.doi.org/10.3390/ijms221910752 |