TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation

Mutation of the tumor suppressor gene, TP53, is associated with abysmal survival outcomes in acute myeloid leukemia (AML). Although it is the most commonly mutated gene in cancer, its occurrence is observed in only 5–10% of de novo AML, and in 30% of therapy related AML (t-AML). TP53 mutation serves...

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Detalles Bibliográficos
Autores principales: George, Binsah, Kantarjian, Hagop, Baran, Natalia, Krocker, Joseph Douglas, Rios, Adan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509740/
https://www.ncbi.nlm.nih.gov/pubmed/34639121
http://dx.doi.org/10.3390/ijms221910782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509740/
https://www.ncbi.nlm.nih.gov/pubmed/34639121
http://dx.doi.org/10.3390/ijms221910782

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