Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity

Elevated levels of free fatty acids (FFAs) have been related to pancreatic beta-cell failure in type 2 diabetes (T2DM), though the underlying mechanisms are not yet fully understood. FFAs have been shown to dysregulate formation of bioactive sphingolipids, such as ceramides and sphingosine-1 phospha...

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Detalles Bibliográficos
Autores principales: Tang, Yadi, Plötz, Thomas, Gräler, Markus H., Gurgul-Convey, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509761/
https://www.ncbi.nlm.nih.gov/pubmed/34639233
http://dx.doi.org/10.3390/ijms221910893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509761/
https://www.ncbi.nlm.nih.gov/pubmed/34639233
http://dx.doi.org/10.3390/ijms221910893

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