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Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity

Elevated levels of free fatty acids (FFAs) have been related to pancreatic beta-cell failure in type 2 diabetes (T2DM), though the underlying mechanisms are not yet fully understood. FFAs have been shown to dysregulate formation of bioactive sphingolipids, such as ceramides and sphingosine-1 phospha...

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Detalles Bibliográficos
Autores principales:	Tang, Yadi, Plötz, Thomas, Gräler, Markus H., Gurgul-Convey, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509761/ https://www.ncbi.nlm.nih.gov/pubmed/34639233 http://dx.doi.org/10.3390/ijms221910893

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