IRF3-mediated pathogenicity in a murine model of human hepatitis A

HAV-infected Ifnar1(-/-) mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved the role...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Lu, Li, You, Misumi, Ichiro, González-López, Olga, Hensley, Lucinda, Cullen, John M., McGivern, David R., Matsuda, Mami, Suzuki, Ryosuke, Sen, Ganes C., Hirai-Yuki, Asuka, Whitmire, Jason K., Lemon, Stanley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509855/
https://www.ncbi.nlm.nih.gov/pubmed/34591933
http://dx.doi.org/10.1371/journal.ppat.1009960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509855/
https://www.ncbi.nlm.nih.gov/pubmed/34591933
http://dx.doi.org/10.1371/journal.ppat.1009960

Ejemplares similares