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IRF3-mediated pathogenicity in a murine model of human hepatitis A

HAV-infected Ifnar1(-/-) mice recapitulate many of the cardinal features of hepatitis A in humans, including serum alanine aminotransferase (ALT) elevation, hepatocellular apoptosis, and liver inflammation. Previous studies implicate MAVS-IRF3 signaling in pathogenesis, but leave unresolved the role...

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Detalles Bibliográficos
Autores principales:	Sun, Lu, Li, You, Misumi, Ichiro, González-López, Olga, Hensley, Lucinda, Cullen, John M., McGivern, David R., Matsuda, Mami, Suzuki, Ryosuke, Sen, Ganes C., Hirai-Yuki, Asuka, Whitmire, Jason K., Lemon, Stanley M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509855/ https://www.ncbi.nlm.nih.gov/pubmed/34591933 http://dx.doi.org/10.1371/journal.ppat.1009960

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