A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents

BACKGROUND: Cholinergic neurons utilize choline (Ch) to synthetize acetylcholine (ACh) and contain a high-affinity Ch transporter, Ch acetyltransferase (ChAT), ACh receptors, and acetylcholinesterase (AChE). As the depletion or malfunction of each component of the cholinergic system has been reporte...

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Detalles Bibliográficos
Autores principales: Tanaka-Kanegae, Ryohei, Hamada, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509891/
https://www.ncbi.nlm.nih.gov/pubmed/34637466
http://dx.doi.org/10.1371/journal.pone.0258420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509891/
https://www.ncbi.nlm.nih.gov/pubmed/34637466
http://dx.doi.org/10.1371/journal.pone.0258420

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