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A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents
BACKGROUND: Cholinergic neurons utilize choline (Ch) to synthetize acetylcholine (ACh) and contain a high-affinity Ch transporter, Ch acetyltransferase (ChAT), ACh receptors, and acetylcholinesterase (AChE). As the depletion or malfunction of each component of the cholinergic system has been reporte...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509891/ https://www.ncbi.nlm.nih.gov/pubmed/34637466 http://dx.doi.org/10.1371/journal.pone.0258420 |