Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synthesized using EDC in the presence of DMAP to provid...

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Detalles Bibliográficos
Autores principales: Ghosh, Arun K., Shahabi, Dana, Yadav, Monika, Kovela, Satish, Anson, Brandon J., Lendy, Emma K., Bonham, Connie, Sirohi, Devika, Brito-Sierra, Carlos A., Hattori, Shin-ichiro, Kuhn, Richard, Mitsuya, Hiroaki, Mesecar, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510097/
https://www.ncbi.nlm.nih.gov/pubmed/34641337
http://dx.doi.org/10.3390/molecules26195782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510097/
https://www.ncbi.nlm.nih.gov/pubmed/34641337
http://dx.doi.org/10.3390/molecules26195782

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