The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site

Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the cell cycle progression and leading to apoptosis. W...

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Detalles Bibliográficos
Autores principales: Boichuk, Sergei, Galembikova, Aigul, Syuzov, Kirill, Dunaev, Pavel, Bikinieva, Firuza, Aukhadieva, Aida, Zykova, Svetlana, Igidov, Nazim, Gankova, Ksenia, Novikova, Maria, Kopnin, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510300/
https://www.ncbi.nlm.nih.gov/pubmed/34641324
http://dx.doi.org/10.3390/molecules26195780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510300/
https://www.ncbi.nlm.nih.gov/pubmed/34641324
http://dx.doi.org/10.3390/molecules26195780

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