Bile-Acid-Appended Triazolyl Aryl Ketones: Design, Synthesis, In Vitro Anticancer Activity and Pharmacokinetics in Rats

A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by detailed spectroscopic techniques such as (1)H and (13)C NMR, HRMS and HPLC. All the synthesized conjugates were evaluated for their cytotoxicity at 10 µM against MCF-7 (human breast adenocarcinoma) and 4T1 (...

Descripción completa

Detalles Bibliográficos
Autores principales: Agarwal, Devesh S., Mazumdar, Samrat, Italiya, Kishan S., Chitkara, Deepak, Sakhuja, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510344/
https://www.ncbi.nlm.nih.gov/pubmed/34641285
http://dx.doi.org/10.3390/molecules26195741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510344/
https://www.ncbi.nlm.nih.gov/pubmed/34641285
http://dx.doi.org/10.3390/molecules26195741

Ejemplares similares