Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the strongest ability. Preliminary work in our laboratory...

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Detalles Bibliográficos
Autores principales: Xu, Simeng, Cao, Yufang, Luo, Yu, Xiao, Di, Wang, Wei, Wang, Zhiren, Yang, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510509/
https://www.ncbi.nlm.nih.gov/pubmed/34641319
http://dx.doi.org/10.3390/molecules26195775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510509/
https://www.ncbi.nlm.nih.gov/pubmed/34641319
http://dx.doi.org/10.3390/molecules26195775

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