A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its level strongly correlates with disease progression. To investigate whether variability in COVID-19 severity partially results from differential IL-6 expression, functional single-nucleotide polymorphisms (SNPs) of IL-6 wer...

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Detalles Bibliográficos
Autores principales: Chen, Tao, Lin, Yu-Xin, Zha, Yan, Sun, Ying, Tian, Jinxiu, Yang, Zhiying, Lin, Shan-Wen, Yu, Fuxun, Chen, Zi-Sheng, Kuang, Bo-Hua, Lei, Jin-Ju, Nie, Ying-jie, Xu, Yonghao, Tian, Dong-Bo, Li, Ying-Zi, Yang, Bin, Xu, Qiang, Yang, Li, Zhong, Nanshan, Zheng, Meizhen, Li, Yimin, Zhao, Jincun, Zhang, Xiang-Yan, Feng, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510538/
https://www.ncbi.nlm.nih.gov/pubmed/34634929
http://dx.doi.org/10.1128/mBio.01372-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510538/
https://www.ncbi.nlm.nih.gov/pubmed/34634929
http://dx.doi.org/10.1128/mBio.01372-21

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