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Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics
The effect of hydrophobicity on antibody aggregation is well understood, and it has been shown that charge calculations can be useful for high-concentration viscosity and pharmacokinetic (PK) clearance predictions. In this work, structure-based charge descriptors are evaluated for their predictive p...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510563/ https://www.ncbi.nlm.nih.gov/pubmed/34632944 http://dx.doi.org/10.1080/19420862.2021.1981805 |