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Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics

The effect of hydrophobicity on antibody aggregation is well understood, and it has been shown that charge calculations can be useful for high-concentration viscosity and pharmacokinetic (PK) clearance predictions. In this work, structure-based charge descriptors are evaluated for their predictive p...

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Detalles Bibliográficos
Autores principales: Thorsteinson, Nels, Gunn, John R., Kelly, Kenneth, Long, Will, Labute, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510563/
https://www.ncbi.nlm.nih.gov/pubmed/34632944
http://dx.doi.org/10.1080/19420862.2021.1981805

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