HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor prote...

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Detalles Bibliográficos
Autores principales: Boczek, Edgar E, Fürsch, Julius, Niedermeier, Marie Laura, Jawerth, Louise, Jahnel, Marcus, Ruer-Gruß, Martine, Kammer, Kai-Michael, Heid, Peter, Mediani, Laura, Wang, Jie, Yan, Xiao, Pozniakovski, Andrej, Poser, Ina, Mateju, Daniel, Hubatsch, Lars, Carra, Serena, Alberti, Simon, Hyman, Anthony A, Stengel, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510580/
https://www.ncbi.nlm.nih.gov/pubmed/34487489
http://dx.doi.org/10.7554/eLife.69377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510580/
https://www.ncbi.nlm.nih.gov/pubmed/34487489
http://dx.doi.org/10.7554/eLife.69377

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