Utility of polygenic embryo screening for disease depends on the selection strategy

Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of expected outcomes. Here we predict, based on the liability threshold model, the expected reduction in complex diseas...

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Detalles Bibliográficos
Autores principales: Lencz, Todd, Backenroth, Daniel, Granot-Hershkovitz, Einat, Green, Adam, Gettler, Kyle, Cho, Judy H, Weissbrod, Omer, Zuk, Or, Carmi, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510582/
https://www.ncbi.nlm.nih.gov/pubmed/34635206
http://dx.doi.org/10.7554/eLife.64716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510582/
https://www.ncbi.nlm.nih.gov/pubmed/34635206
http://dx.doi.org/10.7554/eLife.64716

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