Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of these compounds is presented against four human CA (hCA) isozymes, comprising hCA...

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Detalles Bibliográficos
Autores principales: Riafrecha, Leonardo E., Le Pors, Macarena S., Lavecchia, Martín J., Bua, Silvia, Supuran, Claudiu T., Colinas, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510595/
https://www.ncbi.nlm.nih.gov/pubmed/34607524
http://dx.doi.org/10.1080/14756366.2021.1982933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510595/
https://www.ncbi.nlm.nih.gov/pubmed/34607524
http://dx.doi.org/10.1080/14756366.2021.1982933

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