Cargando…
Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis
The nucleolus of a cell is a critical cellular compartment that is responsible for ribosome biogenesis and plays a central role in tumor progression. Fisetin, a nutraceutical, is a naturally occurring flavonol from the flavonoid group of polyphenols that has anti-cancer effects. Fisetin negatively i...
Autores principales: | Kammerud, Sarah C., Metge, Brandon J., Elhamamsy, Amr R., Weeks, Shannon E., Alsheikh, Heba A., Mattheyses, Alexa L., Shevde, Lalita A., Samant, Rajeev S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510891/ https://www.ncbi.nlm.nih.gov/pubmed/34267320 http://dx.doi.org/10.1038/s41374-021-00642-1 |
Ejemplares similares
-
Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance
por: Elhamamsy, Amr R., et al.
Publicado: (2022) -
Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors
por: Alsheikh, Heba Allah M., et al.
Publicado: (2021) -
Hypoxia re-programs 2′-O-Me modifications on ribosomal RNA
por: Metge, Brandon J., et al.
Publicado: (2020) -
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy
por: Metge, Brandon J., et al.
Publicado: (2023) -
Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer
por: Weeks, Shannon E., et al.
Publicado: (2021)