Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide

Temozolomide (TMZ) is the mainstream chemotherapeutic drug for treating glioblastoma multiforme (GBM), but the intrinsic or acquired chemoresistance to TMZ has become the leading clinical concern, which is related to the repair of DNA alkylation sites by O(6)-methylguanine-DNA methyltransferase (MGM...

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Detalles Bibliográficos
Autores principales: Li, Haisong, Liu, Shuhan, Jin, Rihua, Xu, Haiyang, Li, Yunqian, Chen, Yong, Zhao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511032/
https://www.ncbi.nlm.nih.gov/pubmed/34642308
http://dx.doi.org/10.1038/s41420-021-00654-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511032/
https://www.ncbi.nlm.nih.gov/pubmed/34642308
http://dx.doi.org/10.1038/s41420-021-00654-2

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