Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway

To investigate the mechanism of peripheral neuropathy in Parkinson’s disease (PD), we prepared a PD mice model by long-term exposure of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mimic PD pathology in humans and the sciatic nerves were taken for further research. It turned out that phosp...

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Detalles Bibliográficos
Autores principales: Sun, Li, Jiang, Wen-Wen, Wang, Ye, Yuan, Yong-Sheng, Rong, Zhe, Wu, Jing, Fan, Yi, Lu, Ming, Zhang, Ke-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511120/
https://www.ncbi.nlm.nih.gov/pubmed/34642321
http://dx.doi.org/10.1038/s41420-021-00676-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511120/
https://www.ncbi.nlm.nih.gov/pubmed/34642321
http://dx.doi.org/10.1038/s41420-021-00676-w

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