Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1–Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell types, including immune cells. Isolation of native MgT...

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Detalles Bibliográficos
Autores principales: Naseem, Muhammad Umair, Tajti, Gabor, Gaspar, Attila, Szanto, Tibor G., Borrego, Jesús, Panyi, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511391/
https://www.ncbi.nlm.nih.gov/pubmed/34658872
http://dx.doi.org/10.3389/fphar.2021.733610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511391/
https://www.ncbi.nlm.nih.gov/pubmed/34658872
http://dx.doi.org/10.3389/fphar.2021.733610

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