Cimifugin Suppresses NF-κB Signaling to Prevent Osteoclastogenesis and Periprosthetic Osteolysis

Background: Aseptic loosening of prosthesis (ALP) is one of the most common long-term complications of knee and hip arthroplasty. Wear particle-induced osteoclastogenesis and subsequent periprosthetic osteolysis account for the morbidity of ALP. Here, we investigate the potential of cimifugin (CIM),...

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Detalles Bibliográficos
Autores principales: Duan, Juan, Hu, Xuantao, Li, Tao, Wu, Gen, Dou, Pengcheng, Ouyang, Zhengxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511420/
https://www.ncbi.nlm.nih.gov/pubmed/34658863
http://dx.doi.org/10.3389/fphar.2021.724256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511420/
https://www.ncbi.nlm.nih.gov/pubmed/34658863
http://dx.doi.org/10.3389/fphar.2021.724256

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