Effects of Heparin and Bivalirudin on Thrombin-Induced Platelet Activation: Differential Modulation of PAR Signaling Drives Divergent Prothrombotic Responses

Heparin and bivalirudin are widely used as anticoagulants in the setting of acute thrombosis. In this study, we investigated how these drugs affect the ability of thrombin to generate a prothrombotic platelet response via activation of the protease-activated receptors (PARs) 1 and 4. We examined the...

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Detalles Bibliográficos
Autores principales: Lund, Mikael, Macwan, Ankit S., Tunströmer, Kjersti, Lindahl, Tomas L., Boknäs, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511449/
https://www.ncbi.nlm.nih.gov/pubmed/34660719
http://dx.doi.org/10.3389/fcvm.2021.717835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511449/
https://www.ncbi.nlm.nih.gov/pubmed/34660719
http://dx.doi.org/10.3389/fcvm.2021.717835

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