Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies

Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple amyotrophic lateral sclerosis (ALS) mutations into isogenic cell populations facilitates determination of whether different causal mutations cause...

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Detalles Bibliográficos
Autores principales: Smith, Alec S. T., Chun, Changho, Hesson, Jennifer, Mathieu, Julie, Valdmanis, Paul N., Mack, David L., Choi, Byung-Ok, Kim, Deok-Ho, Bothwell, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511491/
https://www.ncbi.nlm.nih.gov/pubmed/34660586
http://dx.doi.org/10.3389/fcell.2021.728707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511491/
https://www.ncbi.nlm.nih.gov/pubmed/34660586
http://dx.doi.org/10.3389/fcell.2021.728707

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