Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...

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Detalles Bibliográficos
Autores principales: Elliott, Paul R., Leske, Derek, Wagstaff, Jane, Schlicher, Lisa, Berridge, Georgina, Maslen, Sarah, Timmermann, Frederik, Ma, Biao, Fischer, Roman, Freund, Stefan M.V., Komander, David, Gyrd-Hansen, Mads
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511506/
https://www.ncbi.nlm.nih.gov/pubmed/34610306
http://dx.doi.org/10.1016/j.celrep.2021.109777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511506/
https://www.ncbi.nlm.nih.gov/pubmed/34610306
http://dx.doi.org/10.1016/j.celrep.2021.109777

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