A rotamer relay information system in the epidermal growth factor receptor–drug complexes reveals clues to new paradigm in protein conformational change

Cancer cells can escape the effects of chemotherapy through mutations and upregulation of a tyrosine kinase protein called the epidermal growth factor receptor (EGFR). In the past two decades, four generations of tyrosine kinase inhibitors targeting EGFR have been developed. Using comparative struct...

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Detalles Bibliográficos
Autores principales: Hameduh, Tareq, Mokry, Michal, Miller, Andrew D., Adam, Vojtech, Heger, Zbynek, Haddad, Yazan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511715/
https://www.ncbi.nlm.nih.gov/pubmed/34667537
http://dx.doi.org/10.1016/j.csbj.2021.09.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511715/
https://www.ncbi.nlm.nih.gov/pubmed/34667537
http://dx.doi.org/10.1016/j.csbj.2021.09.026

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