Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors

A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5), and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid precursor protein cleaving enzyme 1 (β-secretase, BACE1). Compounds NEA3 and NEA1 exhibited a more potent MAO-B inhibition...

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Detalles Bibliográficos
Autores principales: Venkidath, Anusree, Oh, Jong Min, Dev, Sanal, Amin, Elham, Rasheed, Shebina P., Vengamthodi, Ajeesh, Gambacorta, Nicola, Khames, Ahmed, Abdelgawad, Mohamed A., George, Ginson, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512054/
https://www.ncbi.nlm.nih.gov/pubmed/34641548
http://dx.doi.org/10.3390/molecules26196004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512054/
https://www.ncbi.nlm.nih.gov/pubmed/34641548
http://dx.doi.org/10.3390/molecules26196004

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