Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical outcomes in immunocompromised individuals. Antifungal treatment, based on the use of azoles, is crucial to increase survival rates. However, the recent emergence of azole-resistant A. fumigatus isolates is af...

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Detalles Bibliográficos
Autores principales: Gonzalez-Jimenez, Irene, Lucio, Jose, Roldan, Alejandra, Alcazar-Fuoli, Laura, Mellado, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512156/
https://www.ncbi.nlm.nih.gov/pubmed/34641518
http://dx.doi.org/10.3390/molecules26195975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512156/
https://www.ncbi.nlm.nih.gov/pubmed/34641518
http://dx.doi.org/10.3390/molecules26195975

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