Natural Polyphenols Inhibit the Dimerization of the SARS-CoV-2 Main Protease: The Case of Fortunellin and Its Structural Analogs

3CL-Pro is the SARS-CoV-2 main protease (MPro). It acts as a homodimer to cleave the large polyprotein 1ab transcript into proteins that are necessary for viral growth and replication. 3CL-Pro has been one of the most studied SARS-CoV-2 proteins and a main target of therapeutics. A number of drug ca...

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Detalles Bibliográficos
Autores principales: Panagiotopoulos, Athanasios A., Karakasiliotis, Ioannis, Kotzampasi, Danai-Maria, Dimitriou, Marios, Sourvinos, George, Kampa, Marilena, Pirintsos, Stergios, Castanas, Elias, Daskalakis, Vangelis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512273/
https://www.ncbi.nlm.nih.gov/pubmed/34641612
http://dx.doi.org/10.3390/molecules26196068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512273/
https://www.ncbi.nlm.nih.gov/pubmed/34641612
http://dx.doi.org/10.3390/molecules26196068

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