Structural Insights into Novel 15-Prostaglandin Dehydrogenase Inhibitors

We discovered SW033291 in a high throughput chemical screen aimed at identifying 15-prostaglandin dehydrogenase (15-PGDH) modulators. The compound exhibited inhibitory activity in in vitro biochemical and cell-based assays of 15-PGDH activity. We subsequently demonstrated that this compound, and sev...

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Detalles Bibliográficos
Autores principales: Mallipeddi, Prema L., Zhang, Yongyou, Li, Hongyun, Markowitz, Sanford D., Posner, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512612/
https://www.ncbi.nlm.nih.gov/pubmed/34641449
http://dx.doi.org/10.3390/molecules26195903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512612/
https://www.ncbi.nlm.nih.gov/pubmed/34641449
http://dx.doi.org/10.3390/molecules26195903

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