Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE

Fringes are glycosyltransferases that transfer a GlcNAc to O-fucose residues on Epidermal Growth Factor-like (EGF) repeats. Three Fringes exist in mammals: LUNATIC FRINGE (LFNG), MANIC FRINGE (MFNG), and RADICAL FRINGE (RFNG). Fringe modification of O-fucose on EGF repeats in the NOTCH1 (N1) extrace...

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Detalles Bibliográficos
Autores principales: Pennarubia, Florian, Nairn, Alison V., Takeuchi, Megumi, Moremen, Kelley W., Haltiwanger, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512825/
https://www.ncbi.nlm.nih.gov/pubmed/34641486
http://dx.doi.org/10.3390/molecules26195942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512825/
https://www.ncbi.nlm.nih.gov/pubmed/34641486
http://dx.doi.org/10.3390/molecules26195942

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