Analysis of the Structure-Function-Dynamics Relationships of GALT Enzyme and of Its Pathogenic Mutant p.Q188R: A Molecular Dynamics Simulation Study in Different Experimental Conditions

The third step of the catabolism of galactose in mammals is catalyzed by the enzyme galactose-1-phosphate uridylyltransferase (GALT), a homodimeric enzyme with two active sites located in the proximity of the intersubunit interface. Mutations of this enzyme are associated to the rare inborn error of...

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Detalles Bibliográficos
Autores principales: Verdino, Anna, D’Urso, Gaetano, Tammone, Carmen, Scafuri, Bernardina, Marabotti, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513031/
https://www.ncbi.nlm.nih.gov/pubmed/34641485
http://dx.doi.org/10.3390/molecules26195941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513031/
https://www.ncbi.nlm.nih.gov/pubmed/34641485
http://dx.doi.org/10.3390/molecules26195941

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