In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists are preferable as opioid analgesics. Rubiscol...

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Detalles Bibliográficos
Autores principales: Karasawa, Yusuke, Miyano, Kanako, Fujii, Hideaki, Mizuguchi, Takaaki, Kuroda, Yui, Nonaka, Miki, Komatsu, Akane, Ohshima, Kaori, Yamaguchi, Masahiro, Yamaguchi, Keisuke, Iseki, Masako, Uezono, Yasuhito, Hayashida, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513079/
https://www.ncbi.nlm.nih.gov/pubmed/34641621
http://dx.doi.org/10.3390/molecules26196079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513079/
https://www.ncbi.nlm.nih.gov/pubmed/34641621
http://dx.doi.org/10.3390/molecules26196079

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